Taylor, Ethan

UNCG

There are 13 item/s.

TitleDateViewsBrief Description
A novel method for the selective elimination of HIV infected cells: dexamethasone and procaine as a combination therapy prototype 2011 4930 It has been established that various combinations of three or more antiretroviral drugs will lead to durable inhibition of HIV replication in patients. Despite its success in controlling the infection, highly active antiretroviral therapy (HAART) doe...
Cloning and in vitro characterization of a novel ribosomal frameshifting site in the HIV-1 gag gene 2011 1458 Most retroviruses and various other organisms have a capability of producing multiple protein products from a single RNA species using overlapping genes and taking advantage of ribosomal frameshifting (Jacks T. , 1990; Taylor, 1994). This phenomenon ...
Mechanistic studies of water soluble fullerenes as free radical scavengers, biological antioxidants and NF-kappaB inhibitors 2014 1480 Since their discovery, fullerenes and fullerene derivatives have been the subject of intense research because of their unique properties and potential applications. The combination of a network of conjugated double bonds with high electron affinity m...
Elucidation of the cellular genes, pathways, and biochemical mechanisms involved in HIV stimulation by aqueous tobacco smoke extract. 2014 1452 HIV infection, and tobacco smoking, two areas of major health concern which continue to grow worldwide, both of which have detrimental health effects on the population. The point of intersection where these two health concerns cross is the focus of t...
Targeting the Atypical Chemokine Receptor ACKR3/CXCR7 for the treatment of cancer and other diseases 2015 1790 One of the greatest challenges in fighting cancer is cell targeting and biomarker selection. The Atypical Chemokine Receptor ACKR3/CXCR7 is expressed on many cancer cell types, including breast cancer and glioblastoma, and binds the endogenous ligand...
Nutritional manipulation of HIV/AIDS: the effects of ergothioneine and cultural complementary and alternative medicines on HIV 2015 754 The use of complementary and alternative medicine in minority populations in individuals infected with HIV is prevalent and these cultural practices require laboratory confirmation to determine effectiveness. The manipulation of HIV via nutritional s...
Co-translational genetic switching during protein synthesis: the HIV-1 Nef gene as a paradigm 2016 311 The old maxim of “one gene, one mRNA, one protein” no longer holds, especially with viral genes. It is possible for one mRNA to encode several proteins of unrelated functions in overlapping reading frames of a single oligonucleotide, or for an additi...
Ultra-sensitive and multiplex detection of clinical biomarkers using a SPRi-based sensor 2016 37 Reliable and reproducible biomarker analysis is the main focus of current clinical diagnostic approaches being developed for the sensitive detection and quantification of biomarkers in bodily fluids. Currently used tools are being revised for better ...
Ionic modulation of QPX stability as a nano - switch regulating gene expression in neurons 2016 627 G-quadruplexes (G-QPX) have been the subject of intense research due to their unique structural configuration and potential applications, particularly their functionality in biological process as a novel type of nano–switch. They have been found in c...
Studies of the human CCR3 chemokine receptor: development of a cell line stably expressing CCR3, receptor purification and characterization, and phosphopeptide enrichment methods to study the CCR3 GPCR signaling pathway 2016 493 Studies of the human CCR3 chemokine receptor: development of a cell line stably expressing CCR3, receptor purification and characterization by mass spectrometry, and phosphoproteomic methods to study the CCR3 GPCR signaling pathway. Chemokine Recepto...
Genetic switching during protein synthesis and the role of quadruplexes in HIV-1’s nef gene 2018 126 HIV-1 is still a prominent global public health issue responsible for the deaths of over 1 million people annually. It is a very complex virus that has been extensively studied over the past decade. The virus has adapted several mechanisms to maintai...
Measuring distances between nucleotides using CW- EPR and dual site-directed spin labels to distinguish parallel quadruplexes from B-DNA 2018 125 The proper identification of DNA secondary structure is paramount for determining possible factors that can influence rates of genomic transcription. Structures such as DNA quadruplexes (QPX), which are found in guanine-rich regions of DNA, can have ...
Differential effect of alkali metal ions on the structure and stability of DNA G-Quadruplexes with potential role in the regulation of gene expression 2018 52 G-quadruplexes (G-QPX) have been the subject of great interest in research due to their exclusive structural configuration, functionality and potential roles in biological applications particularly gene regulation and Nano-switch applications. Initia...