Reggio, Patricia

UNCG

There are 10 item/s.

TitleDateViewsBrief Description
The study of allosteric modulator sites at the cannabinoid CB1 receptor 2009 1600 Org 27569, Org 27759 and Org 29647 are the first discovered allosteric modulators of the cannabinoid CB1 receptor. These ligands are thought to bind to "accessory binding sites" at the receptor . Binding of the Org allosteric modulators has been show...
Structural characterization and docking studies of acetylcholine binding proteins. 2009 1316 Neuronal Nicotinic Receptors (NNRs) are ligand gated ion channels located both pre- and postsynaptically in the peripheral and central nervous systems. NNRs are important pharmaceutical targets for schizophrenia, pain, epilepsy, tobacco dependence, T...
In silico refinement of a computer model of GPR55, a cannabinoid receptor 2011 874 Cannabinoid receptors have great therapeutic potential and are important targets in drug discovery. As part of a broader project whose long-term goal is the determination of the basis for the actions of cannabinoids at the molecular level, this resea...
The study of allosteric modulator sites at the cannabinoid CB1 receptor 2009 1600 Org 27569, Org 27759 and Org 29647 are the first discovered allosteric modulators of the cannabinoid CB1 receptor. These ligands are thought to bind to "accessory binding sites" at the receptor . Binding of the Org allosteric modulators has been show...
Building and refinement of an in silico homology model of a novel G protein-coupled receptor: GPR35 2011 1714 Human GPR35 (hGPR35), a recently deorphanized Class A G-protein coupled receptor, has been shown to exhibit prominent expression in immune and gastrointestinal tissues, with additional expression in pancreatic islets, skeletal muscle, lung tissue, an...
Refinement of the conformation of selected transmembrane helices in the cannabinoid receptor GPR55 using conformational memories (CM). 2011 809 GPR55 is a newly de-orphanized cannabinoid receptor which belongs to the class A G-protein coupled receptors (GPCRs) family and binds constitutes of the plant, Cannabis sativa. It has been suggested that the manipulation of GPR55 may have a therapeut...
Computational study of RTI - 371, a positive allosteric modulator of the cannabinoid CB1 receptor 2011 1670 It is now recognized that many G-protein-coupled receptors (GPCRs) contain allosteric binding sites for endogenous and/or synthetic ligands, which are topographically distinct from the agonist-binding site, which is known as the orthosteric site. In ...
Molecular mechanisms of mutant mu-opioid receptors where naloxone acts as an agonist 2013 237 Pain management is often one of the most difficult aspects of treatment for patients suffering from acute or chronic pain. The mu-opioid receptor (MOR) agonist, morphine, and its derivatives are highly used in pain management strategies. However, the...
Creation of a GPR18 homology model using conformational memories 2013 257 G-protein coupled receptors (GPCRs) make up the largest family of eukaryotic membrane receptors, covering a broad range of cellular responses in the body. This wide range of activity makes them important pharmacological targets. In general, all Class...
A model system for understanding cellular signaling of the cannabinoid CB2 receptor via the inhibitory Gi protein 2014 32 One key signaling pathway in the cellular signaling involving G protein coupled receptors (GPCR) is via heterotrimeric G proteins. The first step in GPCR/G protein signaling is the activation of a GPCR by the ligand binding and the next step is the a...