|Use of adsorbent resins in fermentations of bacteria obtained from the red soils of the Kingdom of Jordan and the isolation and structure elucidation of cytotoxic xanthones from an unidentified fungus
||Part I: Adsorbent resins are used in industrial fermentations to help boost the production of antibiotics. The resins used here were utilized to help speed the drug discovery process by eliminating the time-consuming step of freeze-drying the ferment...
|Fingolimod (Gilenya; FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite and the creation of a natural products pure compound database and organized storage system
||Fingolimod (Gilenya; FTY720), a synthetic compound based on the fungal secondary metabolite, myriocin (ISP-I), is a potent immunosuppressant that was approved in September 2010 by the U.S. FDA as a new treatment for multiple sclerosis (MS). Fingolimo...
|Milk thistle flavonolignans: biomimetic synthesis, synthesis of analogues and biological evaluation of synthetic products
||7-O-methylflavonolignans from milk thistle were synthesized by first isolating the seven primary components of silymarin and individually methylating them. Optimization of conditions allowed for each of these seven compounds to be selectively methyla...
|Bioactive natural products: isolation of fungal secondary metabolites and applications of green chemistry
||Natural products have played a significant role in the drug discovery especially in the area of cancer. Over the period of 1940-2010, 50% of the small molecules introduced as anticancer agents were either natural products or directly derived therefro...
|Discovering new structural diversity from unexplored fungi
||Discovery of anticancer drugs with high efficacy coupled with action at novel target sites is necessary to combat cancer. As part of a multidisciplinary project to identify anticancer leads from diverse natural product resources, our group has been s...
|Quantitative analysis of grapefruit constituents involved in diet-drug interactions and modification of the microbial metabolome
||The term "natural product" refers to secondary metabolites produced by living organisms, and therefore encompasses a number of research concentrations ranging from traditional medicines to microbial lead compounds to the impacts of diet on human heal...