|Effects of manganese exposure and iron deficiency on the biology of GABA and norepinephrine
||Both manganese (Mn) and iron (Fe) are dietary metals required for numerous important processes in mammalian systems, and disturbances in the homeostasis of these metals can have deleterious effects, specifically on the central nervous system. In thes...
|Creatine as a neuroprotective agent in manganese-induced neurotoxicity
||Manganese (Mn) is a trace metal that is essential for optimal functioning of mammalian systems. However, excessive exposure to Mn is known to cause an extrapyramidal disease. Presently, Mn-induced neurotoxicity has no cure. In these studies, we exami...
|The effect of manganese neurotoxicity on the Gamma-Aminobutyric acid (GABA) neurotransmitter system
||Manganese (Mn) is an essential metal that functions primarily as a cofactor for metalloenzymes contributing to numerous metabolic pathways. Exposure to excess environmental Mn overwhelms endogenous regulation, and deleterious effects disrupt neurotra...
|The effects of dietary-induced obesity on regional brain iron biology
||Iron is an essential dietary element that supports oxygen transport, nutrient metabolism and protein synthesis; however, dysregulation of iron biology can be detrimental to health. The importance of iron homeostasis is particularly apparent in the br...