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COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Thomas R. Kwapil, Associate Professor (Creator)
Institution
The University of North Carolina at Greensboro (UNCG )
Web Site: http://library.uncg.edu/

Abstract: The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.

Additional Information

Publication
Language: English
Date: 2010
Keywords
velocardiofacial syndrome, COMT Val/Met, psychopathology, psychology