Studies on the rates of ring closure of alpha-omega chlorohydrins with alkali hydroxides

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Judy Ann Davis (Creator)
Janice L. Van Horne (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Kinetic studies were carried out to investigate a possible metallic cation effect on the rate of dehydrohalogenation of alpha-omega chlorohydrins. The rate constants obtained for 2-chloroethanol with alkali hydroxides in 62.5 % dioxane—37.5% H20 at 0° C did not reveal a significant effect although the trend proceeded in the expected direction. While testing for more favorable reaction conditions it was found that the order of ease of reaction for 2-chloroethanol in several aprotic solvents is DMS0 > Dioxane > THF > DMF. The order of the rate of ring closure as a function of ring size was investigated and found to be 3 > 5 > 4 > 7.

Additional Information

Honors Project
Language: English
Date: 1967

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