Effects of n-3 PUFA and n-6 PUFA on plasma lipids, bleeding time, prothrombin time, and liver cholesterol in the gerbil
- UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
- Patricia Carolyn Dunn (Creator)
- Institution
- The University of North Carolina at Greensboro (UNCG )
- Web Site: http://library.uncg.edu/
- Advisor
- Karen L. Graves
Abstract: This dissertation research assessed the effects of n-3 and n-6 PUFA fed in varying combinations on plasma lipids, bleeding time, prothrombin time, and liver cholesterol in 90 adult male gerbils. Gerbils (15 per group) were randomly assigned to one of six dietary treatments. The dietary treatments differed only in type of fat fed. All diets contained 15% fat by weight (14% as the test fat and 1 % as safflower oil). Group 1 consumed 100% of their test fat as lard (SFA), group 2 100% as safflower oil (n-6 PUFA), group 3 100% as MaxEPA oil (n-3 PUFA), group 4 25% n-3 PUFA and 75% n-6 PUFA, group 5 25% n-6 PUFA and 75% n-3 PUFA, and group 6 50% n-6 PUFA and 50% n-3 PUFA. The gerbils remained on the test diets for five weeks. Plasma lipids measured in the study included alpha (HDL-C), beta (LDL-C and VLDLC), total cholesterol, and triglycerides. The only statistically significant effect of dietary treatment on any plasma lipid measure was for triglycerides. The gerbils consuming the 100% n-6 PUFA containing diet exhibited the highest mean triglyceride level. This was significantly different (p <. .05) from mean levels exhibited by those animals consuming the 50% n-6 PUFA 50% n-3 PUFA and 25% n-6 PUFA 75% n-3 PUFA containing diets. No significant overall effects of the dietary treatments were observed for bleeding time, prothrombin time, or liver cholesterol.
Effects of n-3 PUFA and n-6 PUFA on plasma lipids, bleeding time, prothrombin time, and liver cholesterol in the gerbil
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Created on 1/1/1988
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Additional Information
- Publication
- Dissertation
- Language: English
- Date: 1988
- Subjects
- Omega-3 fatty acids
- Fat
- Lipids