Synthetic Approaches to Isocarbacyclin and Analogues as Potential Neuroprotective Agents Against Ischemic Stroke

UNCG Author/Contributor (non-UNCG co-authors, if there are any, appear on document)
Mitchell Croatt, Assistant Professor (Creator)
The University of North Carolina at Greensboro (UNCG )
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Abstract: Isocarbacyclin is a valuable synthetic analogue of prostacyclin with potential neuroprotective effects for the treatment of ischemic stroke. Herein, we describe the synthesis of isocarbacyclin and bicyclic analogues in only 7–10 steps, with the ?-side chain diversified at a late stage. A combination of new reaction design, function-oriented synthesis, and late-stage diversification led to a series of compounds that were tested for their neuroprotective activities. Efforts toward the synthesis of tricyclic analogues of isocarbacyclin, using the same combination of metal-catalyzed reactions, is also described.

Additional Information

Bioorganic & Medicinal Chemistry 2018, 27, 338-342
Language: English
Date: 2019
Isocarbacyclin, Synthesis, Analogues, Neuroprotective, Stroke

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