The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Jimmy T. Efird (Creator)
C. Suzanne Lea (Creator)
Christopher J. Phillips (Creator)
Amanda E. Toland (Creator)
Institution
East Carolina University (ECU )
Web Site: http://www.ecu.edu/lib/

Abstract: The vast majority of cutaneous squamous cell carcinoma (CSCC) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (UVR) exposure. Organ transplant recipients also are an important population at great risk for CSCC. An association has been reported between oral contraceptive (OC) use, human papillomavirus virus (HPV) and cervical cancer, and there could be a similar association for CSCC. The cutaneous HPV ß-E6 protein, a close cousin of the transformative E6 protein underlying anogenital cancers, has been shown to inhibit apoptosis in response to UVR damage and stimulate morphologic transformation in rodent fibroblast cell lines. Furthermore, OC use has been shown to enhance HPV transcription and may contribute to CSCC risk through this pathway.

Additional Information

Publication
Other
Clinical Medicine Insights. Oncology; 5: p. 55-75
Language: English
Date: 2011
Keywords
oral contraceptives, cutaneous squamous cell carcinoma, human papillomavirus virus

Email this document to

This item references:

TitleLocation & LinkType of Relationship
The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinomahttp://hdl.handle.net/10342/5842The described resource references, cites, or otherwise points to the related resource.