Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review
- ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
- Abdel A. Abdel-Rahman (Creator)
- Badr M. Ibrahim (Creator)
- Institution
- East Carolina University (ECU )
- Web Site: http://www.ecu.edu/lib/
Abstract: Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB1R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary knowledge regarding the cannabinoids centrally elicited cardiovascular responses and the possible underlying signaling mechanisms. The current review focuses on the rostral ventrolateral medulla (RVLM) as the primary brainstem nucleus implicated in CB1R-evoked pressor response.
Additional Information
- Publication
- Other
- Journal of Advanced Research; 5:2 p. 137-145
- Language: English
- Date: 2013
- Keywords
- RVLM, PI3K, Cardiovascular, nNOS, Cannabinoids, ERK1/2
| Title | Location & Link | Type of Relationship |
| Cannabinoid receptor 1 signaling in cardiovascular regulating nuclei in the brainstem: A review | http://hdl.handle.net/10342/5767 | The described resource references, cites, or otherwise points to the related resource. |