Total IgA and IgA reactivity to antigen I/II epitopes in HLA-DRB1*04 positive subjects

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Janice S. Blum (Creator)
Judith R. Chin (Creator)
George J. Eckert (Creator)
Margherita Fontana (Creator)
Carlos González-Cabezas (Creator)
Richard L. Gregory (Creator)
James K. Hartsfield (Creator)
V. Wallace McCarlie (Creator)
Lorri A. Morford (Creator)
Mark D. Pescovitz (Creator)
Henry Rodriguez (Creator)
East Carolina University (ECU )
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Abstract: Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential influence of immune responses to I/II. However, it was not known whether secretory IgA (SIgA) responses to the selected epitopes from HLA-DRB1*04 positive subjects were different compared to controls, or across other caries-related factors such as total IgA (TIgA). Thirty-two total subjects were matched according to HLA type, gender, ethnicity and age. HLA genotyping, oral bacterial, immunoglobulin and antibody analyses were performed. A large observed difference emerged with regard to the natural immune reservoir of TIgA in HLA-DRB1*04 positive subjects, specifically, a 27.6% reduction compared to controls. In contrast to all other epitopes studied, HLA-DRB1*04 positive subjects also exhibited reduced reactivity to I/II epitope 834–853. HLA-DRB1*04 positive subjects exhibited lower specific SIgA activity/TIgA to 834–853 and also a lower specific reactivity to 834–853/whole cell S. mutans UA159. Furthermore, HLA-DRB1*04 positive subjects exhibited lower responses to I/II in its entirety. The large observed difference in TIgA and the 834–853 reactivity pattern across multiple measures suggest potentially important connections pertaining to the link between HLA-DRB1*04 and caries.

Additional Information

Open journal of immunology; 3:3 p. 82-92
Language: English
Date: 2013
HLA-II, DRB1, I/II, Dental Caries, Streptococcus mutans, Immunogenetics, IgA, Immunomodulation, DRB1*04

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