Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic but not I1-imidazoline receptor activation in female rats

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Abdel A. Abdel-Rahman (Creator)

Mahmoud M. El-Mas (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses licited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in elemetered female rats. ain methods—The effects of α-methyldopa or rilmenidine on blood pressure (BP) heart rate HR) and their variability were investigated in rats that received liquid diet without or with ethanol 5% w/v) for 12 weeks. To evaluate the effect of each drug on cardiovascular autonomic control (BP nd HR variability) in the absence or presence of ethanol three time-domain indices of hemodynamic ariability were measured: (i) standard deviation of mean arterial pressure (SDMAP) (ii) standard eviation of beat-to-beat intervals and (iii) root mean square of successive differences in R-R ntervals. ey findings—In liquid diet-fed control rats i.p. rilmenidine (600 μg/kg) or α-methyldopa (100 g/kg) reduced BP along with decreases and increases respectively in HR. Both drugs had no effect n HR variability but reduced BP variability (SDMAP) suggesting a reduced vasomotor sympathetic one. Ethanol feeding attenuated reductions in BP and SDMAP evoked by α-methyldopa but not by ilmenidine. ignificance—We conclude that chronic ethanol preferentially compromises α2- but not I1- eceptor-mediated hypotension in female rats probably via modulation of vasomotor sympathetic ctivity. These findings highlight the adequacy of rilmenidine use to lower BP in hypertensive lcoholic females.

Additional Information

Publication

Other

Life Sciences. 84:3-4(January 2009) p. 111-118.

Language: English

Date: 2011

Keywords

Ethanol, rilmenidine, alpha-methyldopa, hypotension, Females, rats

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