Novel autoinducer molecules and uses therefor

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Everett Greenberg (Creator)
Barbara Iglewski (Creator)
Andrew Kende (Creator)
Jared B. J. Milbank (Creator)
James Pearson (Creator)
Everett Pesci (Creator)
East Carolina University (ECU )
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Abstract: Novel bacterial quinolone signal molecules and , more particularly , pseudomonas quinolone signal ('PQS') molecules , e.g. , 2-heptyl-3hydroxy-4-quinolone , and analogs and derivatives thereof are described , Therapeutic compositions containing the molecules , and therapeutic methods , methods of for regulating gene expression , methods for identifying modulators of the autoinducer molecules , and methods of modulating quorum sensing signalling in bacteria using the compounds of the invention are also described.

Additional Information

Language: English
Date: 2002
quinolone, pseudomonas, gene expression

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