The Actin Binding Protein Fesselin is a Member of the Synaptopodin Family

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Brent Beall (Creator)
Joseph M. Chalovich (Creator)
Hans W. Heid (Creator)
Mechthild M. Schroeter (Creator)
East Carolina University (ECU )
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Abstract: Fesselin is a natively unfolded protein that is abundant in avian smooth muscle. Like many natively nfolded proteins fesselin has multiple binding partners including actin myosin calmodulin and ŽÂ±-actinin. Fesselin accelerates actin polymerization and bundles actin. These and other observations uggest that fesselin is a component of the cytoskeleton. We have now cloned fesselin and have etermined the cDNA derived amino acid sequence. We verified parts of the sequence by Edman nalysis and by mass spectroscopy. Our results confirmed fesselin is homologous to human ynaptopodin 2 and belongs to the synaptopodin family of proteins. Originally published Biochem Biophys Res Commun. Vol. 371 No. 3 July 2008

Additional Information

Biochemical and Biophysical Research Communications. 371:3(July 2008) p. 582-586.
Language: English
Date: 2011
fesselin, synaptopodin, myopodin, actin binding protein, actin polymerization, Ca-calmodulin regulation

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