Hox-gene expression as a biomarker for igf-1r therapeutics

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)

Fred Edmond Bertrand (Creator)

Jarrett Thomas Whelan (Creator)

Institution

East Carolina University (ECU )

Web Site: http://www.ecu.edu/lib/

Abstract: This invention provides methods for treating or preventing the onset of a tumor in a subject , wherein the tumor is determined to overexpress a Hox gene , including administering to the subject a therapeutically or prophylactically effective amount of an insulin-like growth factor-1 receptor (IGF-1R) antagonist. The invention also provides methods for determining whether a tumor in a subject is amenable to treatment with an IGF-1R antagonist including determining whether the tumor overexpresses a Hox gene , wherein overexpression of the Hox gene indicates that the tumor is amenable to treatment with an IGF-1R inhibitor.

Additional Information

Publication

Other

Language: English

Date: 2008

Keywords

cancer, genetics

Subjects

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