The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volume

ECU Author/Contributor (non-ECU co-authors, if there are any, appear on document)
Timothy L. Fitzgerald (Creator)
Swapnil D. Kachare (Creator)
Bruce F. Schroeder (Creator)
Olga Schuth (Creator)
Dylan Suttle (Creator)
Kathryn M. Verbanac (Creator)
Nasreen A. Vohra (Creator)
Paul Vos (Creator)
Jan H. Wong (Creator)
Institution
East Carolina University (ECU )
Web Site: http://www.ecu.edu/lib/

Abstract: "Purpose: Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD) and on each of its components (fibroglandular volume and breast volume) by using three-dimensional methods. Materials and Methods: Fibroglandular volume, breast volume, and their ratio, the VBD, were calculated from mammograms before and after WLS by using Volpara™ automated software. Results: For the 80 women included, average body mass index decreased from 46.0 ± 7.22 to 33.7 ± 7.06 kg/m2. Mammograms were performed on average 11.6 ± 9.4 months before and 10.1 ± 7 months after WLS. There was a significant reduction in average breast volume (39.4 % decrease) and average fibroglandular volume (15.5 % decrease), and thus, the average VBD increased from 5.15 to 7.87 % (p < 1 × 10−9) after WLS. When stratified by menopausal status and diabetic status, VBD increased significantly in all groups but only perimenopausal and postmenopausal women and non-diabetics experienced a significant reduction in fibroglandular volume. Conclusions: Breast volume and fibroglandular volume decreased, and VBD increased following WLS, with the most significant change observed in postmenopausal women and non-diabetics. Further studies are warranted to determine how physical and biological alterations in breast density components after WLS may impact breast cancer risk."

Additional Information

Publication
Other
Vohra, N.A., Kachare, S.D., Vos, P. et al. OBES SURG (2016). doi:10.1007/s11695-016-2415-6
Language: English
Date: 2016
Keywords
Volumetric breast density, Weight loss surgery, Fibroglandular volume, Breast cancer, Diabetes, Obesity, Breast density, Breast volume

Email this document to

This item references:

TitleLocation & LinkType of Relationship
The Short-Term Effect of Weight Loss Surgery on Volumetric Breast Density and Fibroglandular Volumehttp://hdl.handle.net/10342/5976The described resource references, cites, or otherwise points to the related resource.