Andrew Shanely Ph.D

There are 41 included publications by Andrew Shanely Ph.D:

TitleDateViewsBrief Description
A 45-Minute Vigorous Exercise Bout Increases Metabolic Rate for 14 Hours 2011 263 Introduction: The magnitude and duration of the elevation in resting energy expenditure after vigorous exercise have not been measured in a metabolic chamber. This study investigated the effects of inserting a 45-min vigorous cycling bout into the da...
Adaptation of Upper Airway Muscles to Chronic Endurance Exercise 2002 209 We tested the hypothesis that chronic endurance exercise is associated with the recruitment of four major upper airway muscles (genioglossus, digastric, sternohyoid, and omohyoid) and results in an increased oxidative capacity and a fast-toward-slow ...
Age and attenuation of exercise-induced myocardial HSP72 accumulation 2003 154 Overexpression of heat shock protein (HSP)72 is associated with cardioprotection. Hyperthermia-induced HSP72 overexpression is attenuated with senes-cence. While exercise also increases myocardial HSP72 in young animals, it is unknown whether this ef...
Bananas as an Energy Source during Exercise: A Metabolomics Approach 2016 200 This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based pr...
Chia Seed Supplementation and Disease Risk Factors in Overweight Women: A Metabolomics Investigation 2012 348 Objective/setting: This study assessed the effectiveness of milled and whole chia seed in altering disease riskfactors in overweight, postmenopausal women using a metabolomics approach.Design/intervention: Subjects were randomized to chia seed (whole...
Combined fruit and vegetable intake are correlated with improved inflammatory and oxidant status from a crosssectional study in a community setting 2012 139 Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined selfreported fruit and v...
A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial 2013 207 Background-The purpose of this study was to assess the effect of 8-weeks ingestion of a commercialized joint pain dietarysupplement (InstaflexTM Joint Support, Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function ...
Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity 2016 294 Consuming carbohydrate- and antioxidant-rich fruits during exercise as a means of supporting and enhancing both performance and health is of interest to endurance athletes. Watermelon (WM) contains carbohydrate, lycopene, L-citrulline, and L-arginine...
Correction of the Enzymatic and Functional Deficits in a Model of Pompe Disease Using Adeno-associated Virus Vectors 2002 166 Pompe disease is a lysosomal storage disease caused by the absence of acid -1,4 glucosidase (GAA). The pathophysiology of Pompe disease includes generalized myopathy of both cardiac and skeletal muscle. We sought to use recombinant adeno-associated v...
Cumulative Effects of Aging and Mechanical Ventilation on In Vitro Diaphragm Function 2003 221 Study objective: Unloading the diaphragm, via mechanical ventilation (MV), results in significant diaphragmaticatrophy, contractile dysfunction, and oxidative stress in young adult animals. Since aging increases skeletal musclesusceptibility to atrop...
Diaphragm Unloading via Controlled Mechanical Ventilation Alters the Gene Expression Profile 2005 233 Rationale: Prolonged controlled mechanical ventilation results in diaphragmatic inactivity and promotes oxidative injury, atrophy, and contractile dysfunction in this important inspiratory muscle. However, the impact of controlled mechanical ventilat...
Effects of a Flavonoid-Rich Juice on Inflammation, Oxidative Stress, and Immunity in Elite Swimmers: A Metabolomics-Based Approach 2013 332 The effects of a flavonoid-rich fresh fruit and vegetable juice (JUICE) on chronic resting and postexercise inflammation, oxidative stress, immune function, and metabolic profiles (metabolomics analysis, gas-chro-matography mass-spectrometry platform...
Effects of a freeze-dried juice blend powder on exercise induced inflammation, oxidative stress, and immune function in cyclists 2014 255 A freeze-dried fruit and vegetable juice powder (JUICE) was investigated as a countermeasure nutritional strategy to exercise-induced inflammation, oxidative stress, and immune perturbations in trained cyclists. Thirty-fourcyclists (25 male, 9 female...
Effects Of Quercetin And EGCG On Mitochondrial Biogenesis And Immunity 2009 39 Purpose: To test the influence of 1000 mg of quercetin (Q) with or without 120 mg of epigallocatechin 3-gallate (EGCG), 400 mg of isoquercetin, and 400 mg of eicosapentaenoic acid and docosahexaenoic acid (Q–EGCG) on exercise performance, muscle mito...
Effects of vitamin E and Lipoic acid on skeletal muscle contractile properties 2001 147 Initial ex- periments were conducted using an in situ rat tibialis anterior (TA) muscle preparation to assess the influence of di- etary antioxidants on muscle contractile properties. Adult Sprague-Dawley rats were divided into two dietary groups: 1)...
Effects of vitamin E deficiency on fatigue and muscle contractile properties 2002 188 Radical-mediated oxidative damage of skeletal muscle membranes has been implicated in the fatigue process. Vitamin E (VE) is a major chain breaking an-tioxidant that has been shown to reduce contraction-mediated oxidative damage. We hypothesized that...
Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon 2014 3885 Adaptogens modulate intracellular signaling and increase expression of heat shock protein 72 (HSP72). Rhodiola rosea (RR) is a medicinal plant with demonstrated adaptogenic properties. The purpose of this study was to measure the in?uence of RR suppl...
High Intensity interval training induces a modest inflammatory response in young active men 2014 318 (VO max). Serum samples were collected during the first and sixth HIIT sessions at rest and immediately, 15, 30, and 45 minutes post-exercise. An acute session of HIIT induced significant increases in interleukin (IL)-6, IL-8, IL-10, tumor necrosis f...
IGF-I activates the mouse type IIb myosin heavy chain gene 2009 300 No Abstract
Immune And Inflammation Responses To A 3-Day Period Of Intensified Running Versus Cycling 2016 407 Functional overreaching has been linked to alterations in immunity and host pathogen defense, but little is known as to whether or not running and cycling evoke different responses. This study compared inflammation, muscle damage and soreness, and in...
Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and a-lipoic acid 2000 196 The purpose of these experiments was to examine the effects of dietary antioxidant supplementation with vitamin E (VE) and a-lipoic acid (a-LA) on biochemical and physiological responses to in vivo myocardial ischemia-reperfusion (I-R) in aged rats. ...
Inflammation And Oxidative Stress Are Lower In Physically fit And Active Adults 2011 35 The objective of this study was to determine if the inverse relationship between perceived physical fitness (pFIT) and exercise frequency (ExFreq) levels and chronic inflammation and oxidative stress exists after making statistical adjustments for co...
Influence of Quercetin Supplementation on Disease Risk Factors in Community-Dwelling Adults 2011 228 Background: In vitro data indicate quercetin has anti-oxidative and anti-inflammatory functions with the potential to lower disease risk factors, but data in human beings are limited.Objective The objective of this study was to investigate the effect...
Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach 2012 304 Red pepper spice (RP) and turmeric (TM) are used as flavorings in foods and for medicinalpurposes. Utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with RP (1 g/d) or TM (2.8 g/d) ...
Long-term quercetin dietary enrichment decreases muscle injury in mdx mice 2015 318 Background & aims: Duchenne muscular dystrophy results from a mutation in the dystrophin gene, which leads to a dystrophin-deficiency. Dystrophic muscle is marked by progressive muscle injury and loss of muscle fibers.Activation of the PGC-1a pathway...
Mechanical Ventilation Depresses Protein Synthesis in the Rat Diaphragm 2004 153 Prolonged mechanical ventilation results in diaphragmatic atrophy and contractile dysfunction in animals. We hypothesized that me-chanical ventilation–induced diaphragmatic atrophy is associated with decreased synthesis of both mixed muscle protein a...
Mechanical ventilation results in progressive contractile dysfunction in the diaphragm 2002 212 These experiments tested the hypothesis that a relatively short duration of controlled mechanical ventilation (MV) will im-pair diaphragmatic maximal speci?c force generation (specific Po) and that this force de?cit will be exacerbated with increased...
Mechanical ventilation-induced oxidative stress in the diaphragm 2003 198 entered by RPM
Mechanical Ventilation–induced Diaphragmatic Atrophy Is Associated with Oxidative Injury and Increased Proteolytic Activity 2002 169 Prolonged mechanical ventilation (MV) results in reduced diaphrag-matic maximal force production and diaphragmatic atrophy. To investigate the mechanisms responsible for MV-induced diaphrag-matic atrophy, we tested the hypothesis that controlled MV r...
Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling 2014 212 Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- and 9-hydroxy-octadecadienoic acid (13-HODE + 9-HODE) and have been linked to oxidative stress, in?ammation, and numerous pathological and physiological states. The purpose of this stu...
Quercetin Supplementation Does not alter Antioxidantstatus in Humans 2010 222 This study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18–85 years) and body mass index (BMI) (16.7–52.7 kg/m2) were studied. Subj...
Quercetin with Vitamin C and Niacin does not affect body Mass or Composition 2011 231 In vitro and animal data suggest that quercetin affects adipogenesis and basal metabolism; however, whether this metabolic effect translates to reductions in body mass or improvement in body composition in humans is unknown. This study investigated 1...
Quercetin's Influence On Exercise Performance And Muscle Mitochondrial Biogenesis 2010 41 Purpose: To determine the influence of 2 wk of quercetin (Q; 1000 mg·d-1) compared with placebo (P) supplementation on exercise performance and skeletal muscle mitochondrial biogenesis in untrained, young adult males (N = 26, age = 20.2 ± 0.4 yr, V·...
Rhodiola rosea exerts antiviral activity in athletes following a competitive marathon race 2015 299 Rhodiola rosea, a medicinal plant with demonstrated adaptogenic properties, has recently been reported to contain active compounds with antimicrobial activity. The goal of this study was to measure the antiviral and antibacterial properties of the bi...
Short-Duration Mechanical Ventilation Enhances Diaphragmatic Fatigue Resistance but Impairs Force Production 2003 187 Study objectives: Mechanical ventilation (MV) is a life-support measure for patients who cannot maintain adequate alveolar ventilation. Following prolonged MV, difficulty in weaning patients from the ventilator canoccur, and it has been postulated th...
Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat 2001 124 These experiments examined the independent effects of short-term exercise and heat stress on myocardial responses during in vivo ischemia-reperfusion (I/R). Female Sprague-Dawley rats (4 mo old) were randomly assigned to one of four experimen- tal gr...
Short-term exercise training improves diaphragm antioxidant capacity and endurance 2000 230 These experiments tested the hypothesis that short-term endurance exercise training would rapidly improve (within 5 days) the diaphragm oxidative/anti-oxidant capacity and protect the diaphragm against contraction-induced oxidative stress. To test th...
Trolox Attenuates Mechanical Ventilation–induced Diaphragmatic Dysfunction and Proteolysis 2004 171 Prolonged mechanical ventilation results in diaphragmatic oxida-tive injury, elevated proteolysis, fiber atrophy, and reduced force-generating capacity. We tested the hypothesis that antioxidant infusion during mechanical ventilation would function a...
Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content 2015 269 Background: Ultrasound imaging is a valuable tool in exercise and sport science research, and has been used to visualize and track real-time movement of muscles and tendons, estimate hydration status in body tissues, and most recently, quantify skele...
The variable plasma quercetin response to 12-week quercetin supplementation in humans 2010 224 Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and l...
Variance in the Acute Inflammatory Response to Prolonged Cycling Is Linked to Exercise Intensity 2012 241 This study investigated the influence of age, body composition, physical fitness, training volume and intensity, and underlying systemic inflammation on exercise-induced inflammation and innate immune function in a heterogeneousgroup of cyclists. Sub...