|NspS, A PotD1 Homolog, Acts as a Spermidine Signal Sensor, Not a Transporter, in Vibrio Cholera
||Biofilm formation is important for the survival of Vibrio cholerae in its natural aquatic environments and within the human intestinal tract. We have previously shown that the absence of PotD1, the periplasmic binding protein for the spermidine ABC t...
|The Effect of Polyamines on Vibrio cholerae Virulence Properties
||Vibrio cholerae is the causative agent of the severe enteric disease, cholera. To be a virulent strain, the bacterium must be able to synthesize both cholera toxin and toxin-coregulated pilus (TCP). TCP has been shown to mediate microcolony formati...
|Characterization of Protein-Protein Interaction Within a Polyamine Responsive Signaling System in Vibrio Cholerae
||The Gram-negative bacterium Vibrio cholerae is a natural inhabitant of aquatic environments and the causative agent of the severe diarrheal disease cholera. This bacterium is able to form biofilms on both abiotic and biotic surfaces. Biofilm formatio...
|Characterization of the Norspermidine/Spermidine Transport Protein, PotD1, in Vibrio cholerae
||Biofilm formation increases antibiotic resistance among bacteria; therefore, a thorough understanding of the proteins and molecules affecting biofilm formation is necessary. PotD1, the substrate binding protein of the PotABCD1 spermidine transport sy...
|Vibriobactin Mediated Biofilm Formation in Vibrio cholerae
||Vibrio cholerae transitions between a free-swimming planktonic lifestyle and a multicellular community called a biofilm, which is used as protection from environmental stressors. The objective of this study was to analyze the role of vibriobactin in ...
|A Novel Norspermidine Responsive Signaling Pathway in Vibrio Cholerae Affecting Biofilm Formation
||Polyamines are a class of simple molecules that are nearly ubiquitous to life. As signals they are involved in cell signaling and cellular processes. In the aquatic pathogen Vibrio cholerae it has been shown that the polyamine norspermidine dramatica...
|Regulation of Biofilm Formation and Norspermidine Production by Iron in Vibrio Cholerae
||Vibrio cholerae is a pathogenic bacterium and the causative agent of the diarrheal disease cholera. V. cholerae is thought to persist in the environment in the form of a biofilm. Biofilm formation is regulated by signals ranging from self produced ...
|Characterization of the norspermidine/spermidine ABC-type transporter, PotABCD1, in Vibrio cholerae
||Vibrio cholerae is an intestinal pathogen that also thrives in aquatic environments through forming biofilms, matrix-bound aggregation of cells offering physical protection from many environmental stressors. Formation of biofilm can be regulated by ...
|Characterization of the NspS-MbaA signaling system controlling biofilm formation from polyamine input to phenotypic output
||Biofilm formation plays a critical role in the infectious cycle of the bacterial pathogen, Vibrio cholerae. The polyamine, norspermidine, has a positive influence on biofilm formation while spermidine has the opposite effect. These influences occur t...